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Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses.
Michael, Benedict D; Dunai, Cordelia; Needham, Edward J; Tharmaratnam, Kukatharmini; Williams, Robyn; Huang, Yun; Boardman, Sarah A; Clark, Jordan J; Sharma, Parul; Subramaniam, Krishanthi; Wood, Greta K; Collie, Ceryce; Digby, Richard; Ren, Alexander; Norton, Emma; Leibowitz, Maya; Ebrahimi, Soraya; Fower, Andrew; Fox, Hannah; Tato, Esteban; Ellul, Mark A; Sunderland, Geraint; Held, Marie; Hetherington, Claire; Egbe, Franklyn N; Palmos, Alish; Stirrups, Kathy; Grundmann, Alexander; Chiollaz, Anne-Cecile; Sanchez, Jean-Charles; Stewart, James P; Griffiths, Michael; Solomon, Tom; Breen, Gerome; Coles, Alasdair J; Kingston, Nathalie; Bradley, John R; Chinnery, Patrick F; Cavanagh, Jonathan; Irani, Sarosh R; Vincent, Angela; Baillie, J Kenneth; Openshaw, Peter J; Semple, Malcolm G; Taams, Leonie S; Menon, David K.
  • Michael BD; Clinical Infection, Microbiology, and Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, L69 7BE, UK. benmic@liverpool.ac.uk.
  • Dunai C; NIHR Health Protection Research Unit (HPRU) in Emerging and Zoonotic Infections at University of Liverpool, Liverpool, L69 7BE, UK. benmic@liverpool.ac.uk.
  • Needham EJ; The Walton Centre NHS Foundation Trust, Liverpool, L9 7BB, UK. benmic@liverpool.ac.uk.
  • Tharmaratnam K; Clinical Infection, Microbiology, and Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, L69 7BE, UK.
  • Williams R; NIHR Health Protection Research Unit (HPRU) in Emerging and Zoonotic Infections at University of Liverpool, Liverpool, L69 7BE, UK.
  • Huang Y; Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0QQ, UK.
  • Boardman SA; Division of Anaesthesia, Department of Medicine, University of Cambridge, Cambridge, CB2 0QQ, UK.
  • Clark JJ; Health Data Science, Institute of Population Health, University of Liverpool, Liverpool, L69 3GF, UK.
  • Sharma P; Oxford Autoimmune Neurology Group, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, OX3 9DU, UK.
  • Subramaniam K; Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.
  • Wood GK; Clinical Infection, Microbiology, and Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, L69 7BE, UK.
  • Collie C; Clinical Infection, Microbiology, and Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, L69 7BE, UK.
  • Digby R; University of Liverpool, Liverpool, L69 7BE, UK.
  • Ren A; Department of Microbiology, Icahn School of Medicine, Mount Sinai, NY, 10029, USA.
  • Norton E; Center for Vaccine Research and Pandemic Preparedness (C-VARPP), Icahn School of Medicine, Mount Sinai, NY, 10029, USA.
  • Leibowitz M; Infection Biology & Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, L3 5RF, UK.
  • Ebrahimi S; Infection Biology & Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, L3 5RF, UK.
  • Fower A; Clinical Infection, Microbiology, and Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, L69 7BE, UK.
  • Fox H; Clinical Infection, Microbiology, and Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, L69 7BE, UK.
  • Tato E; Division of Anaesthesia, Department of Medicine, University of Cambridge, Cambridge, CB2 0QQ, UK.
  • Ellul MA; Division of Anaesthesia, Department of Medicine, University of Cambridge, Cambridge, CB2 0QQ, UK.
  • Sunderland G; Division of Anaesthesia, Department of Medicine, University of Cambridge, Cambridge, CB2 0QQ, UK.
  • Held M; Division of Anaesthesia, Department of Medicine, University of Cambridge, Cambridge, CB2 0QQ, UK.
  • Hetherington C; Division of Anaesthesia, Department of Medicine, University of Cambridge, Cambridge, CB2 0QQ, UK.
  • Egbe FN; Oxford Autoimmune Neurology Group, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, OX3 9DU, UK.
  • Palmos A; Oxford Autoimmune Neurology Group, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, OX3 9DU, UK.
  • Stirrups K; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, SE5 8AF, UK.
  • Grundmann A; NIHR Maudsley Biomedical Research Centre, King's College London, London, SE5 8AF, UK.
  • Chiollaz AC; Clinical Infection, Microbiology, and Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, L69 7BE, UK.
  • Sanchez JC; The Walton Centre NHS Foundation Trust, Liverpool, L9 7BB, UK.
  • Stewart JP; Clinical Infection, Microbiology, and Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, L69 7BE, UK.
  • Griffiths M; Centre for Cell Imaging, Liverpool Shared Research Facilities, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, L69 7ZB, UK.
  • Solomon T; Clinical Infection, Microbiology, and Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, L69 7BE, UK.
  • Breen G; Clinical Infection, Microbiology, and Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, L69 7BE, UK.
  • Coles AJ; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, SE5 8AF, UK.
  • Kingston N; NIHR Maudsley Biomedical Research Centre, King's College London, London, SE5 8AF, UK.
  • Bradley JR; NIHR BioResource, Cambridge University Hospitals NHS Foundation, Cambridge, CB2 0QQ, UK.
  • Chinnery PF; Department of Haematology, University of Cambridge, Cambridge, CB2 0QQ, UK.
  • Cavanagh J; Clinical Neurosciences, Clinical and Experimental Science, Faculty of Medicine, University of Southampton, Southampton, SO17 1BF, UK.
  • Irani SR; Department of Neurology, Wessex Neurological Centre, University Hospital Southampton NHS Foundation Trust, Southampton, SO16 6YD, UK.
  • Vincent A; Département de médecine interne des spécialités (DEMED), University of Geneva, Geneva, CH-1211, Switzerland.
  • Baillie JK; Département de médecine interne des spécialités (DEMED), University of Geneva, Geneva, CH-1211, Switzerland.
  • Openshaw PJ; Infection Biology & Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, L3 5RF, UK.
  • Semple MG; Clinical Infection, Microbiology, and Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, L69 7BE, UK.
  • Taams LS; The Walton Centre NHS Foundation Trust, Liverpool, L9 7BB, UK.
  • Menon DK; The Pandemic Institute, Liverpool, L7 3FA, UK.
Nat Commun ; 14(1): 8487, 2023 Dec 22.
Article en En | MEDLINE | ID: mdl-38135686
ABSTRACT
To understand neurological complications of COVID-19 better both acutely and for recovery, we measured markers of brain injury, inflammatory mediators, and autoantibodies in 203 hospitalised participants; 111 with acute sera (1-11 days post-admission) and 92 convalescent sera (56 with COVID-19-associated neurological diagnoses). Here we show that compared to 60 uninfected controls, tTau, GFAP, NfL, and UCH-L1 are increased with COVID-19 infection at acute timepoints and NfL and GFAP are significantly higher in participants with neurological complications. Inflammatory mediators (IL-6, IL-12p40, HGF, M-CSF, CCL2, and IL-1RA) are associated with both altered consciousness and markers of brain injury. Autoantibodies are more common in COVID-19 than controls and some (including against MYL7, UCH-L1, and GRIN3B) are more frequent with altered consciousness. Additionally, convalescent participants with neurological complications show elevated GFAP and NfL, unrelated to attenuated systemic inflammatory mediators and to autoantibody responses. Overall, neurological complications of COVID-19 are associated with evidence of neuroglial injury in both acute and late disease and these correlate with dysregulated innate and adaptive immune responses acutely.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Lesiones Encefálicas / COVID-19 Límite: Humans Idioma: En Año: 2023 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Lesiones Encefálicas / COVID-19 Límite: Humans Idioma: En Año: 2023 Tipo del documento: Article