Severity of critical illness correlates with CD3-low expression on iNKT-cells among septic surgical patients.
Inflamm Res
; 73(1): 1-4, 2024 Jan.
Article
en En
| MEDLINE
| ID: mdl-38147124
ABSTRACT
BACKGROUND:
iNKT-cells are innate regulatory lymphocytes capable of directing immune and inflammatory responses to sepsis. Repeat stimulation of iNKT-cells leads to the induction of anergy with the emergence of a hyporesponsive CD3low iNKT-cell subpopulation.METHODS:
iNKT-cells were isolated from critical ill surgical patients with sepsis and phenotyped for CD3 expression. This was correlated with degree of severity of illness, as denoted by APACHE-II score.RESULTS:
Comparing healthy volunteers to critically ill septic patients, it was noted that increasing severity of sepsis was associated with increasing frequency of circulating CD3low-iNKT-cell populations.CONCLUSION:
The emergence of CD3low -iNKT-cells may serve as a clinically translatable marker of degree of sepsis-induced immune dysfunction.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Enfermedad Crítica
/
Sepsis
Límite:
Humans
Idioma:
En
Año:
2024
Tipo del documento:
Article