[Tumor-host cell interaction in the microenvironment: new target points for treatment?] / Tumor-Wirtszellen-Interaktion im Mikromilieu: neue Angriffspunkte für die Therapie?

ABSTRACT

BACKGROUND: Primary brain tumors and metastases in the central nervous system (CNS) are characterized by their unique microenvironment, which interacts with neuronal structures and influences structural and adaptive immunity. OBJECTIVE: How significant are various tumor-host interactions from a prognostic and therapeutic perspective? MATERIAL AND METHOD: A literature search was carried out for relevant articles on the topic microenvironment glioblastoma or metastasis through PubMed and Medline. RESULTS: Modern high-throughput methods, such as spatial and single-cell resolution molecular characterization of tumors and their microenvironment enable a detailed mapping of changes and adaptation of individual cells within the microenvironment of tumors; however, treatment approaches based on altered tumor-host cell interactions, such as immune modeling, cell-based treatment methods or checkpoint inhibition have so far not shown any significant advantages for survival. CONCLUSION: A deeper understanding of the complex immune landscape and the microenvironment of metastases of the CNS and intracerebral tumors is essential to optimize future treatment strategies.