Fourteen new 2-benzylbenzofuran glycosides with cardioprotective activity from Heterosmilax yunnanensis.
Bioorg Chem
; 143: 107079, 2024 Feb.
Article
en En
| MEDLINE
| ID: mdl-38185011
ABSTRACT
Fourteen new 2-benzylbenzofuran O-glycosides (1-13, 15) and one new key precursor, diarylacetone (14) were isolated from the roots of Heterosmilax yunnanensis Gagnep, which all have characteristic 2,3,4-O-trisubstituted benzyl. Their structures were elucidated by 1D and 2D NMR, HRESIMS, UV and IR. The isolated compounds were assessed for their cardioprotective activities and compounds 1, 3 and 6 could significantly improve cardiomyocytes viability. Moreover, the mechanistic study revealed that these three compounds could significantly decrease intracellular ROS levels and maintain mitochondrial homeostasis upon hypoxia inducement. Consequently, 1, 3 and 6 might serve as potential lead compounds to prevent myocardial ischemia.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Benzofuranos
/
Raíces de Plantas
/
Glicósidos
Idioma:
En
Año:
2024
Tipo del documento:
Article