Pathophysiological Effects of Autoantibodies in Autoimmune Encephalitides.
Cells
; 13(1)2023 12 20.
Article
en En
| MEDLINE
| ID: mdl-38201219
ABSTRACT
The heterogeneity of autoantibody targets in autoimmune encephalitides presents a challenge for understanding cellular and humoral pathophysiology, and the development of new treatment strategies. Thus, current treatment aims at autoantibody removal and immunosuppression, and is primarily based on data generated from other autoimmune neurological diseases and expert consensus. There are many subtypes of autoimmune encephalitides, which now entails both diseases with autoantibodies targeting extracellular antigens and classical paraneoplastic syndromes with autoantibodies targeting intracellular antigens. Here, we review the current knowledge of molecular and cellular effects of autoantibodies associated with autoimmune encephalitis, and evaluate the evidence behind the proposed pathophysiological mechanisms of autoantibodies in autoimmune encephalitis.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Enfermedades Autoinmunes del Sistema Nervioso
/
Encefalitis
/
Enfermedad de Hashimoto
Tipo de estudio:
Guideline
Límite:
Humans
Idioma:
En
Año:
2023
Tipo del documento:
Article