Your browser doesn't support javascript.
loading
Mesenchymal Stromal Cell Delivery Via Cardiopulmonary Bypass Provides Neuroprotection in a Juvenile Porcine Model.
Sarkislali, Kamil; Kobayashi, Kei; Saric, Nemanja; Maeda, Takuya; Henmi, Soichiro; Somaa, Fahad A; Bansal, Ankush; Tu, Shao Ching; Leonetti, Camille; Hsu, Chao-Hsiung; Li, Jingang; Vyas, Pranav; Kawasawa, Yuka Imamura; Tu, Tsang-Wei; Wang, Paul C; Hanley, Patrick J; Hashimoto-Torii, Kazue; Frank, Joseph A; Jonas, Richard A; Ishibashi, Nobuyuki.
  • Sarkislali K; Center for Neuroscience Research, Children's National Hospital, Washington, DC, USA.
  • Kobayashi K; Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Hospital, Washington, DC, USA.
  • Saric N; Center for Neuroscience Research, Children's National Hospital, Washington, DC, USA.
  • Maeda T; Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Hospital, Washington, DC, USA.
  • Henmi S; Children's National Heart Institute, Children's National Hospital, Washington, DC, USA.
  • Somaa FA; Center for Neuroscience Research, Children's National Hospital, Washington, DC, USA.
  • Bansal A; Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Hospital, Washington, DC, USA.
  • Tu SC; Center for Neuroscience Research, Children's National Hospital, Washington, DC, USA.
  • Leonetti C; Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Hospital, Washington, DC, USA.
  • Hsu CH; Center for Neuroscience Research, Children's National Hospital, Washington, DC, USA.
  • Li J; Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Hospital, Washington, DC, USA.
  • Vyas P; Children's National Heart Institute, Children's National Hospital, Washington, DC, USA.
  • Kawasawa YI; Center for Neuroscience Research, Children's National Hospital, Washington, DC, USA.
  • Tu TW; Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Hospital, Washington, DC, USA.
  • Wang PC; Center for Neuroscience Research, Children's National Hospital, Washington, DC, USA.
  • Hanley PJ; Center for Neuroscience Research, Children's National Hospital, Washington, DC, USA.
  • Hashimoto-Torii K; Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Hospital, Washington, DC, USA.
  • Frank JA; Center for Neuroscience Research, Children's National Hospital, Washington, DC, USA.
  • Jonas RA; Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Hospital, Washington, DC, USA.
  • Ishibashi N; Molecular Imaging Laboratory, Department of Radiology, Howard University, Washington, DC, USA.
JACC Basic Transl Sci ; 8(12): 1521-1535, 2023 Dec.
Article en En | MEDLINE | ID: mdl-38205346
ABSTRACT
Oxidative/inflammatory stresses due to cardiopulmonary bypass (CPB) cause prolonged microglia activation and cortical dysmaturation, thereby contributing to neurodevelopmental impairments in children with congenital heart disease (CHD). This study found that delivery of mesenchymal stromal cells (MSCs) via CPB minimizes microglial activation and neuronal apoptosis, with subsequent improvement of cortical dysmaturation and behavioral alteration after neonatal cardiac surgery. Furthermore, transcriptomic analyses suggest that exosome-derived miRNAs may be the key drivers of suppressed apoptosis and STAT3-mediated microglial activation. Our findings demonstrate that MSC treatment during cardiac surgery has significant translational potential for improving cortical dysmaturation and neurological impairment in children with CHD.
Palabras clave
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Año: 2023 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Año: 2023 Tipo del documento: Article