Degeneration of the cholinergic system in individuals with subjective cognitive decline: A systematic review.
Neurosci Biobehav Rev
; 157: 105534, 2024 Feb.
Article
en En
| MEDLINE
| ID: mdl-38220033
ABSTRACT
BACKGROUND:
Subjective cognitive decline (SCD) is a risk factor for future cognitive impairment and dementia. It is uncertain whether the neurodegeneration of the cholinergic system is already present in SCD individuals. We aimed to review the current evidence about the association between SCD and biomarkers of degeneration in the cholinergic system.METHOD:
Original articles were extracted from three databases Pubmed, Web of Sciences, and Scopus, in January 2023. Two researchers screened the studies independently.RESULTS:
A total of 11 research articles were selected. SCD was mostly based on amnestic cognitive complaints. Cholinergic system biomarkers included neuroimaging markers of basal forebrain volume, functional connectivity, transcranial magnetic stimulation, or biofluid. The evidence showed associations between basal forebrain atrophy, poorer connectivity of the cholinergic system, and SCDCONCLUSIONS:
Degenerative changes in the cholinergic system can be present in SCD. Subjective complaints may help when identifying individuals with brain changes that are associated with cognitive impairment. These findings may have important implications in targeting individuals that may benefit from cholinergic-target treatments at very early stages of neurodegenerative diseases.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Enfermedad de Alzheimer
/
Disfunción Cognitiva
/
Prosencéfalo Basal
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
/
Systematic_reviews
Límite:
Humans
Idioma:
En
Año:
2024
Tipo del documento:
Article