Synthesis of [3 H]Org24598 using in-house prepared [3 H]MeI.
J Labelled Comp Radiopharm
; 67(3): 91-103, 2024 Mar.
Article
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| MEDLINE
| ID: mdl-38221662
ABSTRACT
The synthesis of tritium-labelled glycine transporter 1 inhibitor Org24598 is reported. Because of the instability of the Org24598 skeleton under hydrogenation conditions, a synthetic approach using an in-house prepared tritium-labelled alkylating agent ([3 H]MeI, SA = 26.2 Ci/mmol) was employed. Alternative methods of labelling are discussed.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Proteínas de Transporte de Glicina en la Membrana Plasmática
/
Glicina
Idioma:
En
Año:
2024
Tipo del documento:
Article