Seven-up acts in neuroblasts to specify adult central complex neuron identity and initiate neuroblast decommissioning.
Development
; 151(3)2024 Feb 01.
Article
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| MEDLINE
| ID: mdl-38230563
ABSTRACT
An unanswered question in neurobiology is how are diverse neuron cell types generated from a small number of neural stem cells? In the Drosophila larval central brain, there are eight bilateral Type 2 neuroblast (T2NB) lineages that express a suite of early temporal factors followed by a different set of late temporal factors and generate the majority of the central complex (CX) neurons. The early-to-late switch is triggered by the orphan nuclear hormone receptor Seven-up (Svp), yet little is known about how this Svp-dependent switch is involved in specifying CX neuron identities. Here, we (1) birth date the CX neurons P-EN and P-FN (early and late, respectively); (2) show that Svp is transiently expressed in all early T2NBs; and (3) show that loss of Svp expands the population of early born P-EN neurons at the expense of late born P-FN neurons. Furthermore, in the absence of Svp, T2NBs fail decommissioning and abnormally extend their lineage into week-old adults. We conclude that Svp is required to specify CX neuron identity, as well as to initiate T2NB decommissioning.
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Banco de datos:
MEDLINE
Asunto principal:
Proteínas de Drosophila
/
Células-Madre Neurales
Límite:
Animals
Idioma:
En
Año:
2024
Tipo del documento:
Article