Diversity and Evolutionary Analysis of Venom Insulin Derived from Cone Snails.
Toxins (Basel)
; 16(1)2024 01 09.
Article
en En
| MEDLINE
| ID: mdl-38251250
ABSTRACT
Cone snails possess a diverse array of novel peptide toxins, which selectively target ion channels and receptors in the nervous and cardiovascular systems. These numerous novel peptide toxins are a valuable resource for future marine drug development. In this review, we compared and analyzed the sequence diversity, three-dimensional structural variations, and evolutionary aspects of venom insulin derived from different cone snail species. The comparative analysis reveals that there are significant variations in the sequences and three-dimensional structures of venom insulins from cone snails with different feeding habits. Notably, the venom insulin of some piscivorous cone snails exhibits a greater similarity to humans and zebrafish insulins. It is important to emphasize that these venom insulins play a crucial role in the predatory strategies of these cone snails. Furthermore, a phylogenetic tree was constructed to trace the lineage of venom insulin sequences, shedding light on the evolutionary interconnections among cone snails with diverse diets.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Ponzoñas
/
Insulina
Límite:
Animals
/
Humans
Idioma:
En
Año:
2024
Tipo del documento:
Article