Sequential Treatment Failure With Aztreonam-Ceftazidime-Avibactam Followed by Cefiderocol Due to Preexisting and Acquired Mechanisms in a New Delhi Metallo-ß-lactamase-Producing Escherichia coli Causing Fatal Bloodstream Infection.
Clin Infect Dis
; 78(6): 1425-1428, 2024 Jun 14.
Article
en En
| MEDLINE
| ID: mdl-38289725
ABSTRACT
We report a fatal case of New Delhi metallo-ß-lactamase (NDM)-producing Escherichia coli in a bacteremic patient with sequential failure of aztreonam plus ceftazidime-avibactam followed by cefiderocol. Acquired resistance was documented phenotypically and mediated through preexisting and acquired mutations. This case highlights the need to rethink optimal treatment for NDM-producing organisms.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Beta-Lactamasas
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Aztreonam
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Ceftazidima
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Cefalosporinas
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Bacteriemia
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Insuficiencia del Tratamiento
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Combinación de Medicamentos
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Escherichia coli
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Infecciones por Escherichia coli
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Compuestos de Azabiciclo
Límite:
Humans
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Male
Idioma:
En
Año:
2024
Tipo del documento:
Article