A novel chitosan antioxidant bearing sulfhydryl group: Synthesis, characterization and activity assessment.
Int J Biol Macromol
; 261(Pt 1): 129816, 2024 Mar.
Article
en En
| MEDLINE
| ID: mdl-38290626
ABSTRACT
To improve the antioxidant activity, sulfhydryl groups (-SH) were introduced into chitosan. Acylated chitosan derivatives, chitosan cationic salt derivatives, hydroxypropyl trimethylammonium chloride chitosan quaternary ammonium salt (HACC) derivatives and N,N,N-trimethyl chitosan iodine (TMC) derivatives were obtained. The chitosan derivatives were characterized by FTIR and 1H NMR to confirm the successful synthesis. Ellman's reagent was used to determine that the compound contained free sulfhydryl groups. The water solubility and thermal stability of chitosan and derivatives were evaluated. The antioxidant activities of the derivatives were verified, including DPPH radical scavenging activity, superoxide anion radical scavenging activity and reducing power activity. The novel chitosan derivatives showed excellent antioxidant activities. Toxicity assay used L929 cells proved that the derivatives had no significant toxic. The results showed that the chitosan derivatives bearing sulfhydryl groups described in this paper has a certain antioxidant effect, which provides a practical approach for further study of chitosan.
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1
Banco de datos:
MEDLINE
Asunto principal:
Quitosano
/
Antioxidantes
Idioma:
En
Año:
2024
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Article