α-Silylated Diazoalkynes: New Tools for Bioconjugation of Proteins.
Chemistry
; 30(19): e202302807, 2024 Apr 02.
Article
en En
| MEDLINE
| ID: mdl-38305813
ABSTRACT
α-Silylated diazoalkynes are stabilized diazo compounds that can selectively react with carboxylic residues in buffered aqueous media. In-situ fluoride induced desilylation increases this reactivity, leading to a very fast reaction. Application to the selective functionalization of RNase A, followed by post-functionalization using click chemistry, is described. These new reagents expand the toolbox for native protein modification at carboxylic residues.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Compuestos Azo
/
Proteínas
Idioma:
En
Año:
2024
Tipo del documento:
Article