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Aortic rupture following acute aortitis in a patient with head and neck carcinoma treated with nivolumab: a rare but severe immune-related adverse event.
Ohno, Yuki; Ueki, Yushi; Oshima, Shusuke; Omata, Jo; Yokoyama, Yusuke; Takahashi, Takeshi; Shodo, Ryusuke; Yamazaki, Keisuke; Horii, Arata.
  • Ohno Y; Department of Otolaryngology Head and Neck Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1-757, Asahimachi-dori, Chuo-ku, Niigata City, Niigata, 950-8510, Japan.
  • Ueki Y; Department of Otolaryngology Head and Neck Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1-757, Asahimachi-dori, Chuo-ku, Niigata City, Niigata, 950-8510, Japan. ucuekin@gmail.com.
  • Oshima S; Department of Otolaryngology Head and Neck Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1-757, Asahimachi-dori, Chuo-ku, Niigata City, Niigata, 950-8510, Japan.
  • Omata J; Department of Otolaryngology Head and Neck Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1-757, Asahimachi-dori, Chuo-ku, Niigata City, Niigata, 950-8510, Japan.
  • Yokoyama Y; Department of Otolaryngology Head and Neck Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1-757, Asahimachi-dori, Chuo-ku, Niigata City, Niigata, 950-8510, Japan.
  • Takahashi T; Department of Otolaryngology Head and Neck Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1-757, Asahimachi-dori, Chuo-ku, Niigata City, Niigata, 950-8510, Japan.
  • Shodo R; Department of Otolaryngology Head and Neck Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1-757, Asahimachi-dori, Chuo-ku, Niigata City, Niigata, 950-8510, Japan.
  • Yamazaki K; Department of Otolaryngology Head and Neck Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1-757, Asahimachi-dori, Chuo-ku, Niigata City, Niigata, 950-8510, Japan.
  • Horii A; Department of Otolaryngology Head and Neck Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1-757, Asahimachi-dori, Chuo-ku, Niigata City, Niigata, 950-8510, Japan.
Eur Arch Otorhinolaryngol ; 281(4): 2037-2040, 2024 Apr.
Article en En | MEDLINE | ID: mdl-38308762
ABSTRACT

INTRODUCTION:

Immune-related adverse events (irAEs) due to immune checkpoint inhibitors may lead to discontinuation and treatment-related death. Acute aortitis is a rare but severe irAE. CASE PRESENTATION A 67-year-old man with recurrent lower gingival carcinoma received nivolumab therapy. Twenty-three months later, he experienced chest compression, which resulted in syncope. Following a whole-body computed tomography (CT) scanning, which revealed diffuse thickening of the aorta, and systemic assessments of the causes of aortitis, he was diagnosed with acute aortitis due to irAE. Nivolumab discontinuation and oral steroids improved CT findings. However, 11 months after nivolumab discontinuation, he developed an aortic aneurysmal rupture. Endovascular aortic repair rescued him. A durable anti-cancer response was still observed 4 months after the aortic rupture.

CONCLUSION:

Although severe irAE, such as acute aortitis, occurred, the patient may still achieve a durable response. A broad examination and prompt treatment of irAE can help improve the patient's survival.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Rotura de la Aorta / Aortitis / Carcinoma Límite: Aged / Humans / Male Idioma: En Año: 2024 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Rotura de la Aorta / Aortitis / Carcinoma Límite: Aged / Humans / Male Idioma: En Año: 2024 Tipo del documento: Article