Histopathological findings from the investigation of paediatric acute hepatitis of unknown aetiology, United Kingdom 2022.
J Pediatr Gastroenterol Nutr
; 78(3): 534-538, 2024 Mar.
Article
en En
| MEDLINE
| ID: mdl-38327256
ABSTRACT
In 2022, there were global reports of increased numbers of acute hepatitis not explained by hepatitis A-E virus infection in children. This manuscript summarises histopathology results from 20 patients in the United Kingdom who underwent liver transplant or had a liver biopsy as part of aetiological investigations. All available histopathological samples were reviewed centrally as part of the outbreak investigation. A working group comprised of infection specialists, hepatologists and histopathologists met virtually to review the cases, presentation, investigations and histopathology. All 20 liver samples had evidence of inflammation without significant interface activity, and submassive confluent pan-lobular or multilobular hepatocellular necrosis. Overall, the predominant histopathological findings were of acute nonspecific hepatitis with submassive hepatic necrosis and central vein perivenulitis and endothelitis. Histopathological findings were a poor indicator of aetiology.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Trasplante de Hígado
/
Hepatitis
/
Hepatopatías
Tipo de estudio:
Diagnostic_studies
Límite:
Child
/
Humans
Idioma:
En
Año:
2024
Tipo del documento:
Article