Creation of a pandemic memory by tracing COVID-19 infections and immunity in Luxembourg (CON-VINCE).
BMC Infect Dis
; 24(1): 179, 2024 Feb 09.
Article
en En
| MEDLINE
| ID: mdl-38336649
ABSTRACT
BACKGROUND:
During the COVID-19 pandemic swift implementation of research cohorts was key. While many studies focused exclusively on infected individuals, population based cohorts are essential for the follow-up of SARS-CoV-2 impact on public health. Here we present the CON-VINCE cohort, estimate the point and period prevalence of the SARS-CoV-2 infection, reflect on the spread within the Luxembourgish population, examine immune responses to SARS-CoV-2 infection and vaccination, and ascertain the impact of the pandemic on population psychological wellbeing at a nationwide level.METHODS:
A representative sample of the adult Luxembourgish population was enrolled. The cohort was followed-up for twelve months. SARS-CoV-2 RT-qPCR and serology were conducted at each sampling visit. The surveys included detailed epidemiological, clinical, socio-economic, and psychological data.RESULTS:
One thousand eight hundred sixty-five individuals were followed over seven visits (April 2020-June 2021) with the final weighted period prevalence of SARS-CoV-2 infection of 15%. The participants had similar risks of being infected regardless of their gender, age, employment status and education level. Vaccination increased the chances of IgG-S positivity in infected individuals. Depression, anxiety, loneliness and stress levels increased at a point of study when there were strict containment measures, returning to baseline afterwards.CONCLUSION:
The data collected in CON-VINCE study allowed obtaining insights into the infection spread in Luxembourg, immunity build-up and the impact of the pandemic on psychological wellbeing of the population. Moreover, the study holds great translational potential, as samples stored at the biobank, together with self-reported questionnaire information, can be exploited in further research. TRIAL REGISTRATION Trial registration number NCT04379297, 10 April 2020.Palabras clave
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1
Banco de datos:
MEDLINE
Asunto principal:
COVID-19
Tipo de estudio:
Risk_factors_studies
Límite:
Adult
/
Humans
País como asunto:
Europa
Idioma:
En
Año:
2024
Tipo del documento:
Article