AIE luminogen labeled polymeric micelles for biological imaging and chemotherapy.
Colloids Surf B Biointerfaces
; 235: 113792, 2024 Mar.
Article
en En
| MEDLINE
| ID: mdl-38340417
ABSTRACT
In this study, an amphiphilic polymer FA-CS-DBA-CHO with aggregation-induced emission (AIE) feature was prepared by introducing 4-(diphenylamino)benzaldehyde derivative (DBA-CHO), imine bond and folic acid (FA) to the molecular structure of chitosan (CS). The amphiphilicity drove the polymer to self-assemble into micelles, and paclitaxel (PTX) could be solubilized in the hydrophobic core. Due to the excellent AIE effect, FA-CS-DBA-CHO exhibited strong cellular imaging capability. The pH-sensitive imine bond in the polymer allowed for accurate drug release in acidic environment. Both in vitro and in vivo studies demonstrated that the PTX-loaded FA-CS-DBA-CHO micelles could significantly inhibit the growth of tumor cells but without any notable toxicity. This micellar system was excellent carrier for bioimaging and chemotherapeutic drug delivery.
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Banco de datos:
MEDLINE
Asunto principal:
Micelas
/
Antineoplásicos Fitogénicos
Idioma:
En
Año:
2024
Tipo del documento:
Article