Microstructural Changes in the Brainstem Auditory Pathway in Children With Hearing Loss.
Otol Neurotol
; 45(3): e170-e176, 2024 Mar 01.
Article
en En
| MEDLINE
| ID: mdl-38361295
ABSTRACT
OBJECTIVE:
To assess the utility of diffusion tensor imaging of the auditory pathway in children with sensorineural hearing loss (SNHL). STUDYDESIGN:
Retrospective cohort study.SETTING:
A single academic tertiary children's hospital. PATIENTS Sixteen pediatric patients with bilateral SNHL of at least moderate severity in the poorer ear (eight male; mean age, 5.3 ± 4.9 yrs). Controls consisted of age- and sex-matched children with normal hearing who were imaged for nonotologic, non-neurologic medical concerns and found to have normal magnetic resonance imaging (MRI).INTERVENTIONS:
Three Tesla MRI scanners were used for diffusion tensor imaging. MAIN OUTCOMEMEASURES:
Quantitative diffusion tensor metrics were extracted from the superior olivary nucleus (SON), inferior colliculus (IC), and ipsilateral fiber tracts between the SON and IC delineated by tractography.RESULTS:
We identified differences in fractional anisotropy of the SON between the SNHL cohort and controls (0.377 ± 0.056 vs. 0.422 ± 0.052; p = 0.009), but not in the IC. There were no differences in the mean diffusivity (MD) values in the IC and SON. Among younger children (≤5 yrs), MD was decreased in the SNHL cohort compared with controls in the IC (0.918 ± 0.051 vs. 1.120 ± 0.142; p < 0.001). However, among older children (>5 yrs), there were no differences in MD (1.124 ± 0.198 vs. 0.997 ± 0.103; p = 0.119). There were no differences in MD or fractional anisotropy in the white matter fibers of the IC-SON tract.CONCLUSIONS:
Our results suggest abnormal neural tracts along the central auditory pathway among children with SNHL. Longitudinal studies should assess the prognostic value of these MRI-based findings for assessing long-term outcomes and determining intervention efficacy.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Sordera
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Sustancia Blanca
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Pérdida Auditiva Sensorineural
Tipo de estudio:
Observational_studies
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Prognostic_studies
Límite:
Adolescent
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Child
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Child, preschool
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Humans
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Infant
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Male
Idioma:
En
Año:
2024
Tipo del documento:
Article