Unraveling the intricacies of host-pathogen interaction through single-cell genomics.
Microbes Infect
; : 105313, 2024 Feb 16.
Article
en En
| MEDLINE
| ID: mdl-38369008
ABSTRACT
Single-cell genomics provide researchers with tools to assess host-pathogen interactions at a resolution previously inaccessible. Transcriptome analysis, epigenome analysis, and immune profiling techniques allow for a better comprehension of the heterogeneity underlying both the host response and infectious agents. Here, we highlight technological advancements and data analysis workflows that increase our understanding of host-pathogen interactions at the single-cell level. We review various studies that have used these tools to better understand host-pathogen dynamics in a variety of infectious disease contexts, including viral, bacterial, and parasitic diseases. We conclude by discussing how single-cell genomics can advance our understanding of host-pathogen interactions.
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MEDLINE
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En
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2024
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Article