Detection of Artemisinin Resistance Marker Kelch-13 469Y in Plasmodium falciparum, South Kivu, Democratic Republic of the Congo, 2022.
Am J Trop Med Hyg
; 110(4): 653-655, 2024 Apr 03.
Article
en En
| MEDLINE
| ID: mdl-38377612
ABSTRACT
Partial artemisinin resistance has emerged in East Africa, posing a threat to malaria control across the continent. The Democratic Republic of the Congo carries one of the heaviest malaria burdens globally, and the South Kivu province directly borders current artemisinin resistance hot spots, but indications of such resistance have not been observed so far. We assessed molecular markers of antimalarial drug resistance in 256 Plasmodium falciparum isolates collected in 2022 in South Kivu, Democratic Republic of the Congo. One isolate carried the P. falciparum Kelch-13 469Y variant, a marker associated with partial artemisinin resistance and decreased lumefantrine susceptibility in Uganda. In addition, the multidrug resistance-1 mutation pattern suggested increased lumefantrine tolerance.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Malaria Falciparum
/
Artemisininas
/
Antimaláricos
Límite:
Humans
País como asunto:
Africa
Idioma:
En
Año:
2024
Tipo del documento:
Article