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28 NICUs participating in a quality improvement collaborative targeting early-onset sepsis antibiotic use.
Payton, Kurlen S E; Bennett, Mihoko V; Schulman, Joseph; Benitz, William E; Stellwagen, Lisa; Darmstadt, Gary L; Quinn, Jenny; Kristensen-Cabrera, Alexandria I; Breault, Courtney C; Bolaris, Michael; Lefrak, Linda; Merrill, Jeff; Sharek, Paul J.
  • Payton KSE; Department of Pediatrics, Division of Neonatology, Cedars-Sinai Medical Center, Los Angeles, CA, USA. kurlen.payton@cshs.org.
  • Bennett MV; California Perinatal Quality Care Collaborative (CPQCC), Stanford, CA, USA. kurlen.payton@cshs.org.
  • Schulman J; California Perinatal Quality Care Collaborative (CPQCC), Stanford, CA, USA.
  • Benitz WE; Department of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine, Stanford, CA, USA.
  • Stellwagen L; CA Department of Health Care Services, California Children's Services, Sacramento, CA, USA.
  • Darmstadt GL; Department of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine, Stanford, CA, USA.
  • Quinn J; Department of Pediatrics, Division of Academic General Pediatrics, University of California San Diego School of Medicine, San Diego, CA, USA.
  • Kristensen-Cabrera AI; Prematurity Research Center, Department of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine, Stanford, CA, USA.
  • Breault CC; California Perinatal Quality Care Collaborative (CPQCC), Stanford, CA, USA.
  • Bolaris M; California Perinatal Quality Care Collaborative (CPQCC), Stanford, CA, USA.
  • Lefrak L; California Perinatal Quality Care Collaborative (CPQCC), Stanford, CA, USA.
  • Merrill J; Department of Pediatrics, Division of Infectious Disease, Harbor-University of California Los Angeles Medical Center, Los Angeles, CA, USA.
  • Sharek PJ; California Department of Public Health, Center for Health Care Quality, Health Care Associated Infections Program, Richmond, CA, USA.
J Perinatol ; 44(7): 1061-1068, 2024 Jul.
Article en En | MEDLINE | ID: mdl-38378826
ABSTRACT

OBJECTIVE:

There is widespread overuse of antibiotics in neonatal intensive care units (NICUs). The objective of this study was to safely reduce antibiotic use in participating NICUs by targeting early-onset sepsis (EOS) management. STUDY

DESIGN:

Twenty-eight NICUs participated in this statewide multicenter antibiotic stewardship quality improvement collaborative. The primary aim was to reduce the total monthly mean antibiotic utilization rate (AUR) by 25% in participant NICUs.

RESULT:

Aggregate AUR was reduced by 15.3% (p < 0.001). There was a wide range in improvement among participant NICUs. There were no increases in EOS rates or nosocomial infection rates related to the intervention.

CONCLUSION:

Participation in this multicenter NICU antibiotic stewardship collaborative targeting EOS was associated with an aggregate reduction in antibiotic use. This study informs efforts aimed at sustaining improvements in NICU AURs.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Unidades de Cuidado Intensivo Neonatal / Mejoramiento de la Calidad / Sepsis Neonatal / Programas de Optimización del Uso de los Antimicrobianos / Antibacterianos Límite: Female / Humans / Newborn Idioma: En Año: 2024 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Unidades de Cuidado Intensivo Neonatal / Mejoramiento de la Calidad / Sepsis Neonatal / Programas de Optimización del Uso de los Antimicrobianos / Antibacterianos Límite: Female / Humans / Newborn Idioma: En Año: 2024 Tipo del documento: Article