Cocaine use and head and neck cancer risk: A pooled analysis in the International Head and Neck Cancer Epidemiology Consortium.
Cancer Med
; 13(3): e7019, 2024 Feb.
Article
en En
| MEDLINE
| ID: mdl-38400665
ABSTRACT
BACKGROUND:
Cocaine is an illegal recreational drug used worldwide, yet little is known about whether cocaine inhalation (smoking/snorting) increases the risk of head and neck cancer (HNC).METHODS:
The analyses were conducted by pooling data from three case-control studies with 1639 cases and 2506 controls from the International Head and Neck Cancer Epidemiology Consortium. Epidemiologic data, including cocaine use histories, were obtained in face-to-face interviews. Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated using hierarchical logistic regression models.RESULTS:
Controlling for cumulative tobacco and alcohol use, we observed a weak positive association between cocaine use and HNC (ORever vs. never = 1.35, 95% CI 0.96, 1.90). In stratified analysis, while we did not detect associations among never tobacco or alcohol users due to the limited sample size, the association with cocaine use was observed among tobacco users and alcohol drinkers. ORs for ever and high cumulative use (>18 times) versus never use were 1.40 (95% CI 0.98, 2.00) and 1.66 (95% CI 1.03, 2.69) among tobacco users, and 1.34 (95% CI 0.93, 1.92) and 1.59 (95% CI 1.00, 2.51) among alcohol drinkers, respectively.CONCLUSION:
In this pooled analysis, we observed a weak positive association between cocaine inhalation and HNC risk. Our findings provide preliminary evidence of the potential carcinogenic effect of cocaine on HNC. Because of study limitations, including limited number of cocaine users, confounding, and heterogeneity across studies, future investigations will require larger studies with more detailed information on cocaine use history.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Cocaína
/
Neoplasias de Cabeza y Cuello
Límite:
Humans
Idioma:
En
Año:
2024
Tipo del documento:
Article