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Flexible and Transparent Metal Oxide/Metal Grid Hybrid Interfaces for Electrophysiology and Optogenetics.
Chen, Zhiyuan; Yin, Rose T; Obaid, Sofian N; Tian, Jinbi; Chen, Sheena W; Miniovich, Alana N; Boyajian, Nicolas; Efimov, Igor R; Lu, Luyao.
  • Chen Z; Department of Biomedical Engineering, The George Washington University, Washington, DC 20052, USA.
  • Yin RT; Department of Biomedical Engineering, The George Washington University, Washington, DC 20052, USA.
  • Obaid SN; Department of Biomedical Engineering, The George Washington University, Washington, DC 20052, USA.
  • Tian J; Department of Biomedical Engineering, The George Washington University, Washington, DC 20052, USA.
  • Chen SW; Department of Biomedical Engineering, The George Washington University, Washington, DC 20052, USA.
  • Miniovich AN; Department of Biomedical Engineering, The George Washington University, Washington, DC 20052, USA.
  • Boyajian N; Department of Biomedical Engineering, The George Washington University, Washington, DC 20052, USA.
  • Efimov IR; Department of Biomedical Engineering, The George Washington University, Washington, DC 20052, USA.
  • Lu L; Department of Biomedical Engineering, The George Washington University, Washington, DC 20052, USA.
Adv Mater Technol ; 5(8)2020 Aug.
Article en En | MEDLINE | ID: mdl-38404692
ABSTRACT
Flexible and transparent microelectrodes and interconnects provide the unique capability for a wide range of emerging biological applications, including simultaneous optical and electrical interrogation of biological systems. For practical biointerfacing, it is important to further improve the optical, electrical, electrochemical, and mechanical properties of the transparent conductive materials. Here, high-performance microelectrodes and interconnects with high optical transmittance (59-81%), superior electrochemical impedance (5.4-18.4 Ω cm2), and excellent sheet resistance (5.6-14.1 Ω sq-1), using indium tin oxide (ITO) and metal grid (MG) hybrid structures are demonstrated. Notably, the hybrid structures retain the superior mechanical properties of flexible MG other than brittle ITO with no changes in sheet resistance even after 5000 bending cycles against a small radius at 5 mm. The capabilities of the ITO/MG microelectrodes and interconnects are highlighted by high-fidelity electrical recordings of transgenic mouse hearts during co-localized programmed optogenetic stimulation. In vivo histological analysis reveals that the ITO/MG structures are fully biocompatible. Those results demonstrate the great potential of ITO/MG interfaces for broad fundamental and translational physiological studies.
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Texto completo: 1 Banco de datos: MEDLINE Idioma: En Año: 2020 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Idioma: En Año: 2020 Tipo del documento: Article