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RNA aptamer reveals nuclear TDP-43 pathology is an early aggregation event that coincides with STMN-2 cryptic splicing and precedes clinical manifestation in ALS.
Spence, Holly; Waldron, Fergal M; Saleeb, Rebecca S; Brown, Anna-Leigh; Rifai, Olivia M; Gilodi, Martina; Read, Fiona; Roberts, Kristine; Milne, Gillian; Wilkinson, Debbie; O'Shaughnessy, Judi; Pastore, Annalisa; Fratta, Pietro; Shneider, Neil; Tartaglia, Gian Gaetano; Zacco, Elsa; Horrocks, Mathew H; Gregory, Jenna M.
  • Spence H; Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.
  • Waldron FM; Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.
  • Saleeb RS; EaStCHEM School of Chemistry, University of Edinburgh, Edinburgh, UK.
  • Brown AL; IRR Chemistry Hub, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.
  • Rifai OM; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London, UK.
  • Gilodi M; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK.
  • Read F; RNA System Biology Lab, Instituto Italiano di Tecnologia, Genoa, Italy.
  • Roberts K; Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.
  • Milne G; Department of Pathology, NHS Grampian Tissue Biorepository, Aberdeen, UK.
  • Wilkinson D; Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.
  • O'Shaughnessy J; Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.
  • Pastore A; EaStCHEM School of Chemistry, University of Edinburgh, Edinburgh, UK.
  • Fratta P; IRR Chemistry Hub, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.
  • Shneider N; The Maurice Wohl Institute, King's College London, London, UK.
  • Tartaglia GG; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London, UK.
  • Zacco E; Department of Neurology, Center for Motor Neuron Biology and Disease, Columbia University, New York, NY, USA.
  • Horrocks MH; RNA System Biology Lab, Instituto Italiano di Tecnologia, Genoa, Italy.
  • Gregory JM; RNA System Biology Lab, Instituto Italiano di Tecnologia, Genoa, Italy.
Acta Neuropathol ; 147(1): 50, 2024 03 05.
Article en En | MEDLINE | ID: mdl-38443601
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Aptámeros de Nucleótidos / Esclerosis Amiotrófica Lateral Límite: Humans Idioma: En Año: 2024 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Aptámeros de Nucleótidos / Esclerosis Amiotrófica Lateral Límite: Humans Idioma: En Año: 2024 Tipo del documento: Article