Anti-proliferative, -migratory and -clonogenic effects of long-lasting nitric oxide release in HepG2 cells.
Chem Commun (Camb)
; 60(26): 3527-3530, 2024 Mar 26.
Article
en En
| MEDLINE
| ID: mdl-38450546
ABSTRACT
Nitric oxide (NO) holds promise as a cytotoxic agent against tumors, but its gaseous nature and short half-life hinder direct administration to tumor tissues. Herein, we present novel 6,9-disubstituted purine derivatives designed to ensure sustained NO release, followed by study of their significant anti-proliferative, anti-migratory, and anti-clonogenic effects on HepG2 cell lines, highlighting NO release as a potent effector for treating hepatocellular carcinoma.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Carcinoma Hepatocelular
/
Neoplasias Hepáticas
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Antineoplásicos
Límite:
Humans
Idioma:
En
Año:
2024
Tipo del documento:
Article