Prediction of severe radiation-induced oral mucositis in locally advanced nasopharyngeal carcinoma using the combined systemic immune-inflammatory index and prognostic nutritional index.
Eur Arch Otorhinolaryngol
; 281(5): 2627-2635, 2024 May.
Article
en En
| MEDLINE
| ID: mdl-38472492
ABSTRACT
OBJECTIVE:
Severe radiation-induced oral mucositis (sRIOM) can seriously affect patients' quality of life and treatment compliance. This study was to investigate the utility of the systemic immune-inflammatory index (SII) and prognostic nutritional index (PNI) in predicting sRIOM in patients with locally advanced nasopharyngeal carcinoma (LANPC).METHODS:
295 patients with LANPC were retrospectively screened. The pre-radiotherapy SII and PNI were calculated based on peripheral blood samples. A receiver operating characteristic (ROC) curve was used to determine the cut-off value. Logistic regression was used for univariate and multivariate analyses. Patients were classified into three groups based on the SII-PNI score score of 2, high SII (> cut-off value) and low PNI (≤ cut-off value); score of 1, either high SII or low PNI; score of 0, neither high SII nor low PNI.RESULTS:
The SII-PNI demonstrated significant predictive ability for sRIOM occurrence, as evidenced by an area under the curve (AUC) of 0.738. The incidence rates of sRIOM with SII-PNI score of 2, 1, and 0 were 73.86%, 44.35%, and 18.07%, respectively. Multivariate analysis confirmed that the SII-PNI score was an independent risk factor for sRIOM.CONCLUSION:
The SII-PNI score is a reliable and convenient indicator for predicting sRIOM in patients with LANPC.Palabras clave
Texto completo:
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Banco de datos:
MEDLINE
Asunto principal:
Estomatitis
/
Carcinoma
/
Neoplasias Nasofaríngeas
Límite:
Humans
Idioma:
En
Año:
2024
Tipo del documento:
Article