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Clinicopathological features of adult T-cell leukemia/lymphoma with T-follicular helper phenotype.
Muto, Reiji; Miyoshi, Hiroaki; Nakashima, Kazutaka; Takeuchi, Mai; Hamasaki, Makoto; Ohshima, Koichi.
  • Muto R; Department of Pathology, National Hospital Organization (NHO), Kumamoto Medical Center, Kumamoto, Japan.
  • Miyoshi H; Department of Pathology, Kurume University School of Medicine, Kurume, Japan.
  • Nakashima K; Department of Pathology, Fukuoka University School of Medicine, Fukuoka, Japan.
  • Takeuchi M; Department of Pathology, Kurume University School of Medicine, Kurume, Japan.
  • Hamasaki M; Department of Pathology, Kurume University School of Medicine, Kurume, Japan.
  • Ohshima K; Department of Pathology, Kurume University School of Medicine, Kurume, Japan.
Cancer Med ; 13(6): e7050, 2024 Mar.
Article en En | MEDLINE | ID: mdl-38506241
ABSTRACT

AIMS:

T-follicular helper (TFH) cells are effector T-cells that are crucial for B-cell selection and differentiation. T-cell lymphomas derived from TFH cells have distinct characteristics. Additionally, in the World Health Organization (WHO) classification 5th edition, three lymphomas were introduced as independent disease entities with TFH cell origin. We aimed to investigate the clinicopathological features of adult T-cell leukemia/lymphoma (ATLL) with a TFH phenotype (TFHP). METHODS AND

RESULTS:

We performed TFH immunohistochemistry analysis of five biomarkers for the biopsy specimen, with TFHP being indicated by a positive result for more than two markers. Among 75 cases of ATLL, 37.3% of them showed TFHP. Compared with cases of ATLL without TFHP, cases of ATLL with TFHP showed higher C-reactive protein levels (p = 0.0219) and increased high endothelial venule proliferation (p = 0.024). However, there were no significant between-group differences in overall survival as well as other clinical and morphological findings. Furthermore, there was no significant between-group difference in TFH markers and FOXP3 expression.

CONCLUSION:

Some patients with ATLL may present a TFHP, which should not preclude the diagnosis of ATLL. Although presenting a TFHP does not affect prognosis, it is important to identify cases of ATLL with a TFHP since it may inform future treatment strategies.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Leucemia-Linfoma de Células T del Adulto / Linfoma Límite: Adult / Humans Idioma: En Año: 2024 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Leucemia-Linfoma de Células T del Adulto / Linfoma Límite: Adult / Humans Idioma: En Año: 2024 Tipo del documento: Article