An Artificial Gut/Absorption Simulator: Understanding the Impact of Absorption on In Vitro Dissolution, Speciation, and Precipitation of Amorphous Solid Dispersions.

Jain, Krutika Meena Harish; Hou, Hao Helen; Siegel, Ronald A

Jain, Krutika Meena Harish; Hou, Hao Helen; Siegel, Ronald A.

Jain KMH; Department of Pharmaceutics, University of Minnesota, Minneapolis, Minnesota 55455, United States.
Hou HH; Small Molecule Pharmaceutical Sciences, Genentech Inc., South San Francisco, California 94080, United States.
Siegel RA; Department of Pharmaceutics, University of Minnesota, Minneapolis, Minnesota 55455, United States.

Mol Pharm ; 21(4): 1884-1899, 2024 Apr 01.

Article en En | MEDLINE | ID: mdl-38512389

Asunto(s)

Absorción Gastrointestinal; Polímeros; Solubilidad; Cristalización; Liberación de Fármacos; Polímeros/química

Palabras clave

absorption; amorphous solid dispersion; biorelevant dissolution; hollow fibers; membrane transport; precipitation; supersaturation

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Polímeros / Absorción Gastrointestinal Idioma: En Año: 2024 Tipo del documento: Article

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PubMed Links

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Polímeros / Absorción Gastrointestinal Idioma: En Año: 2024 Tipo del documento: Article