Gestational alloimmune liver disease with alpha thalassaemia in a neonate.
BMJ Case Rep
; 17(3)2024 Mar 21.
Article
en En
| MEDLINE
| ID: mdl-38514166
ABSTRACT
A term baby presented with cholestatic jaundice since birth. She was diagnosed as gestational alloimmune liver disease-neonatal haemochromatosis (GALD-NH) on evaluation. The baby received intravenous immunoglobulin (IVIG) and recovered gradually from the illness. She was also diagnosed with alpha thalassaemia during the course of evaluation, confirmed by genetic testing. NH is a very rare disorder that results in fetal loss or neonatal death due to liver failure. NH is now known to be a phenotypic expression of GALD. Worldwide, NH is seen in less than one in a million pregnancies. The mortality rate of GALD has traditionally been around 80% with almost all babies needing liver transplantation, with advent of maternal and neonatal IVIG treatment, this has reduced significantly. There is no reported case of GALD-NH treated successfully with IVIG from India. Here, we report an interesting case of GALD-NH with alpha thalassaemia.
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Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Fallo Hepático
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Talasemia alfa
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Enfermedades Fetales
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Hemocromatosis
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Enfermedades del Recién Nacido
Límite:
Female
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Humans
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Newborn
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Pregnancy
Idioma:
En
Año:
2024
Tipo del documento:
Article