ABSTRACT
Objective:
This study aims to comprehensively examine and assess the changes and significance of irisin levels in individuals with
carotid atherosclerosis (CAS)
who are concurrently dealing with
obesity.
Method:
A total of 156 CAS
patients admitted between March 2020 and March 2022 were categorized into CAS normal weight (C1), CAS
overweight (C2), and CAS
obesity (C3) groups based on BMI. Simultaneously, 80 healthy
adults from the same period comprised the
control group (C0). The study conducted a comparative
analysis of biochemical indexes,
serum irisin levels, and
carotid artery ultrasounds across all groups. Correlation analyses and diagnostic assessments for
serum irisin in
obesity with
carotid atherosclerosis were executed using
ROC curves.
Results:
Statistically significant differences were observed in
cholesterol (TC),
triglyceride (TG),
high-density lipoprotein cholesterol (HDL-C),
low-density lipoprotein cholesterol (LDL-C),
serum homocysteine (Hcy), and irisin levels among all groups (P < .05). Obese CAS
patients exhibited higher levels of TC, TG, LDL-C, and Hcy, with notably lower levels of HDL-C and irisin compared to other groups (P < .05). Significant variations in
carotid artery ultrasound intima-media thickness (IMT) and Crouse scores were also evident among all groups (P < .05). Specifically, IMT and Crouse scores were higher in obese CAS
patients compared to other groups (P < .05). Correlation
analysis results indicated a significant negative correlation between irisin and TC, TG, LDL-C, Hcy, IMT, and Crouse score (P < .05). Conversely, irisin exhibited a significant positive correlation with HDL-C levels (P < .05). The
ROC curve analysis for the diagnostic value of irisin in
obesity with CAS revealed an area under the curve of 0.957.
Conclusions:
Serum irisin levels are significantly reduced in CAS
patients, particularly those with
overweight and obese. Additionally, irisin levels are closely associated with
patients'
blood lipids,
homocysteine levels, and the severity of
atherosclerosis.