Minor ergosteroids and a 19-nor labdane-type diterpenoid with anti-inflammatory effects from Ganoderma lucidum.
Phytochemistry
; 222: 114052, 2024 Jun.
Article
en En
| MEDLINE
| ID: mdl-38518849
ABSTRACT
A chemical investigation on the fruiting bodies of Ganoderma lucidum led to the isolation and identification of five undescribed ergosteroids including two des-D-steroids (3 and 4) and one rare 6/6/7/5-fused carbon skeletal ergosterol (5) along with one 19-nor labdane-type diterpenoid (6). Their structures including their absolute configurations, were assigned by spectroscopic methods, ECD calculations, and X-ray diffraction analysis. In addition, the anti-inflammatory activities of all the isolates were evaluated. The results indicated that compound 1 can significantly down-regulate the protein expression of iNOS and COX-2 at 20 µM in LPS- stimulated RAW264.7 cells.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Reishi
/
Diterpenos
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Ergosterol
Límite:
Animals
Idioma:
En
Año:
2024
Tipo del documento:
Article