Glucose Uptake-Stimulating Metabolites from Aerial Parts of Centaurea sicula.
J Nat Prod
; 87(4): 1179-1186, 2024 04 26.
Article
en En
| MEDLINE
| ID: mdl-38528772
ABSTRACT
A comprehensive phytochemical investigation of aerial parts obtained from Centaurea sicula L. led to the isolation of 14 terpenoids (1-14) and nine polyphenols (15-23). The sesquiterpenoid group (1-11) included three structural families, namely, elemanolides (1-6), eudesmanolides (7 and 8), and germacranolides (9-11) with four unreported secondary metabolites (5-8), whose structure has been determined by extensive spectroscopic analysis, including 1D/2D NMR, HR-MS, and chemical conversion. Moreover, an unprecedented alkaloid, named siculamide (24), was structurally characterized, and a possible biogenetic origin was postulated. Inspired by the traditional use of the plant and in the frame of ongoing research on compounds with potential activity on metabolic syndrome, all the isolated compounds were evaluated for their stimulation of glucose uptake, disclosing remarkable activity for dihydrocnicin (10) and the lignan salicifoliol (15).
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Centaurea
/
Componentes Aéreos de las Plantas
/
Glucosa
Idioma:
En
Año:
2024
Tipo del documento:
Article