Chemoenzymatic Synthesis of Selegiline: An Imine Reductase-Catalyzed Approach.
Molecules
; 29(6)2024 Mar 16.
Article
en En
| MEDLINE
| ID: mdl-38542964
ABSTRACT
(R)-Homobenzylic amines are key structural motifs present in (R)-selegiline, a drug indicated for the treatment of early-stage Parkinson's disease. Herein, we report a new short chemoenzymatic approach (in 2 steps) towards the synthesis of (R)-selegiline via stereoselective biocatalytic reductive amination as the key step. The imine reductase IR36-M5 mutant showed high conversion (97%) and stereoselectivity (97%) toward the phenylacetone and propargyl amine substrates, offering valuable biocatalysts for synthesizing alkylated homobenzylic amines.
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Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Oxidorreductasas
/
Selegilina
Idioma:
En
Año:
2024
Tipo del documento:
Article