Hepatitis B virus markers in children with acute leukemia: the effect of chemotherapy.
J Med Virol
; 15(1): 29-33, 1985 Jan.
Article
en En
| MEDLINE
| ID: mdl-3855443
ABSTRACT
Hepatitis B virus markers were tested in the serum of 49 children with acute leukemia on clinical presentation and during subsequent chemotherapy. Hepatitis B surface antigenemia was observed in only six patients (12%), none of whom progressed to chronic infection. Chemotherapy had a marked suppressive effect on the production of antibodies to hepatitis B virus antigens and overt infection occurred in two children after suppression of protective immunity. Evidence of liver damage was frequently observed and was largely independent of serologic data. These results indicate that active immunization with hepatitis B vaccine may not find a clear place in this clinical setting.
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Banco de datos:
MEDLINE
Asunto principal:
Leucemia
/
Leucemia Linfoide
/
Hepatitis B
/
Antígenos de Superficie de la Hepatitis B
Límite:
Child
/
Female
/
Humans
/
Male
Idioma:
En
Año:
1985
Tipo del documento:
Article