Effect of MSX1 on the cellular function of cardiomyocytes.
Gene
; 916: 148419, 2024 Jul 20.
Article
en En
| MEDLINE
| ID: mdl-38556116
ABSTRACT
MSX1 (Muscle Segment Homeobox 1) has pleiotropic effects in various tissues, including cardiomyocytes, while the effect of MSX1 on cardiomyocyte cellular function was not well known. In this study, we used AC16 cell culture, real-time fluorescence quantitative PCR (qPCR), protein blotting (Western blot), flow cytometry apoptosis assay and lactate dehydrogenase (LDH) ELISA (Enzyme-Linked Immunosorbnent Assay) to investigate the effect of the MSX1 gene on cardiomyocyte function. The results showed that MSX1 plays a protective role against hypoxia of cardiomyocytes. However, further studies are required to fully understand the role of MSX1 in the regulation of LDH expression in different cell types and under different conditions.
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Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Apoptosis
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Miocitos Cardíacos
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Factor de Transcripción MSX1
Límite:
Animals
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Humans
Idioma:
En
Año:
2024
Tipo del documento:
Article