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[Techniques for quantifying endotypes of obstructive sleep apnea].
Li, G S; Peng, C; Shi, Y; Wang, Y; Chen, B Y.
  • Li GS; Department of Respiratory and Critical Care Medicine, Tianjin Medical University General Hospital, Tianjin 300052, China.
  • Peng C; Department of Respiratory and Critical Care Medicine, Tianjin Medical University General Hospital, Tianjin 300052, China.
  • Shi Y; Department of Respiratory and Critical Care Medicine, Tianjin Medical University General Hospital, Tianjin 300052, China.
  • Wang Y; Department of Respiratory and Critical Care Medicine, Tianjin Medical University General Hospital, Tianjin 300052, China.
  • Chen BY; Department of Respiratory and Critical Care Medicine, Tianjin Medical University General Hospital, Tianjin 300052, China.
Zhonghua Jie He He Hu Xi Za Zhi ; 47(4): 383-388, 2024 Apr 12.
Article en Zh | MEDLINE | ID: mdl-38599817
ABSTRACT
Obstructive sleep apnea (OSA) is the frequent occurrence of apnea and/or hypopnea during sleep, leading to intermittent hypoxia, hypercapnia, and disruption of sleep architecture, further resulting in multisystem damage. The pathophysiological mechanisms include abnormal anatomical structure, low arousal threshold, high loop gain, and poor muscle reactivity, etc. As there are individual differences in the underlying mechanisms of OSA (i.e. endotypes), the effectiveness of treatment and prognosis may also vary according to these characteristics. Understanding the endotype of OSA is critical to understanding which patients are most likely to benefit from non-invasive ventilation therapy. Quantification of endotypes is central to the precision treatment of OSA and may provide the basis for accurate clinical treatment of OSA based on endotypes.
Asunto(s)

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Apnea Obstructiva del Sueño Límite: Humans Idioma: Zh Año: 2024 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Apnea Obstructiva del Sueño Límite: Humans Idioma: Zh Año: 2024 Tipo del documento: Article