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Characteristics of SARS-CoV-2 Omicron BA.5 variants in Shanghai after ending the zero-COVID policy in December 2022: a clinical and genomic analysis.
Liu, Pengcheng; Cai, Jiehao; Tian, He; Li, Jingjing; Lu, Lijuan; Xu, Menghua; Zhu, Xunhua; Fu, Xiaomin; Wang, Xiangshi; Zhong, Huaqing; Jia, Ran; Ge, Yanling; Zhu, Yanfeng; Zeng, Mei; Xu, Jin.
  • Liu P; Department of Clinical Laboratory, National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, China.
  • Cai J; Department of Infectious Diseases, National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, China.
  • Tian H; Department of Infectious Diseases, National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, China.
  • Li J; Department of Infectious Diseases, National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, China.
  • Lu L; Department of Clinical Laboratory, National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, China.
  • Xu M; Department of Clinical Laboratory, National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, China.
  • Zhu X; Department of Clinical Laboratory, National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, China.
  • Fu X; Department of Infectious Diseases, National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, China.
  • Wang X; Department of Infectious Diseases, National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, China.
  • Zhong H; Department of Clinical Laboratory, National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, China.
  • Jia R; Department of Clinical Laboratory, National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, China.
  • Ge Y; Department of Infectious Diseases, National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, China.
  • Zhu Y; Department of Infectious Diseases, National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, China.
  • Zeng M; Department of Infectious Diseases, National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, China.
  • Xu J; Department of Clinical Laboratory, National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, China.
Front Microbiol ; 15: 1372078, 2024.
Article en En | MEDLINE | ID: mdl-38605705
ABSTRACT

Introduction:

An unprecedented surge of Omicron infections appeared nationwide in China in December 2022 after the adjustment of the COVID-19 response policy. Here, we report the clinical and genomic characteristics of SARS-CoV-2 infections among children in Shanghai during this outbreak.

Methods:

A total of 64 children with symptomatic COVID-19 were enrolled. SARS-CoV-2 whole genome sequences were obtained using next-generation sequencing (NGS) technology. Patient demographics and clinical characteristics were compared between variants. Phylogenetic tree, mutation spectrum, and the impact of unique mutations on SARS-CoV-2 proteins were analysed in silico.

Results:

The genomic monitoring revealed that the emerging BA.5.2.48 and BF.7.14 were the dominant variants. The BA.5.2.48 infections were more frequently observed to experience vomiting/diarrhea and less frequently present cough compared to the BF.7.14 infections among patients without comorbidities in the study. The high-frequency unique non-synonymous mutations were present in BA.5.2.48 (NQ241K) and BF.7.14 (nsp2V94L, nsp12L247F, SC1243F, ORF7aH47Y) with respect to their parental lineages. Of these mutations, SC1243F, nsp12L247F, and ORF7aH47Y protein were predicted to have a deleterious effect on the protein function. Besides, nsp2V94L and nsp12L247F were predicted to destabilize the proteins.

Discussion:

Further in vitro to in vivo studies are needed to verify the role of these specific mutations in viral fitness. In addition, continuous genomic monitoring and clinical manifestation assessments of the emerging variants will still be crucial for the effective responses to the ongoing COVID-19 pandemic.
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Texto completo: 1 Banco de datos: MEDLINE Idioma: En Año: 2024 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Idioma: En Año: 2024 Tipo del documento: Article