The NF&#954;B Signaling Pathway Is Involved in the Pathophysiological Process of Preeclampsia.

The NFκB Signaling Pathway Is Involved in the Pathophysiological Process of Preeclampsia.

Li, Yaxi; Zhu, Qinying; He, Ruifen; Du, Junhong; Qin, Xue; Li, Yi; Liang, Xiaolei; Wang, Jing.

Li Y; The First Clinical Medical College of Lanzhou University, Lanzhou, China.
Zhu Q; The First Clinical Medical College of Lanzhou University, Lanzhou, China.
He R; The First Clinical Medical College of Lanzhou University, Lanzhou, China.
Du J; The First Clinical Medical College of Lanzhou University, Lanzhou, China.
Qin X; The First Clinical Medical College of Lanzhou University, Lanzhou, China.
Li Y; The First Clinical Medical College of Lanzhou University, Lanzhou, China.
Liang X; Department of Obstetrics and Gynecology, Key Laboratory for Gynecologic Oncology Gansu Province, The First Hospital of Lanzhou University, Lanzhou, China.
Wang J; Department of Obstetrics and Gynecology, The First Hospital of Lanzhou University, Lanzhou, China.

Geburtshilfe Frauenheilkd ; 84(4): 334-345, 2024 Apr.

Article en En | MEDLINE | ID: mdl-38618576

ABSTRACT

The high prevalence of preeclampsia (PE) is a major cause of maternal and fetal mortality and affects the long-term prognosis of both mother and baby. Termination of pregnancy is currently the only effective treatment for PE, so there is an urgent need for research into its pathogenesis and the development of new therapeutic approaches. The NFκB family of transcription factors has an essential role in inflammation and innate immunity. In this review, we summarize the role of NFκB in normal and preeclampsia pregnancies, the role of NFκB in existing treatment strategies, and potential NFκB treatment strategies.

Palabras clave

NFκB; inflammation; preeclampsia (PE); pregnancy; treatment

Texto completo: 1 Banco de datos: MEDLINE Idioma: En Año: 2024 Tipo del documento: Article