Fruit but not vegetable consumption is beneficial for low prevalence of colorectal polyps in a high-risk population: findings from a Chinese Lanxi Pre-colorectal Cancer Cohort study.
Eur J Nutr
; 63(5): 1759-1769, 2024 Aug.
Article
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| MEDLINE
| ID: mdl-38622294
ABSTRACT
PURPOSE:
The available evidence regarding the role of fruit and vegetable consumption in the development of colorectal polyps remains inconclusive, and there is a lack of data on different histopathologic features of polyps. We aimed to evaluate the associations of fruit and vegetable consumption with the prevalence of colorectal polyps and its subtypes in a high-risk population in China.METHODS:
We included 6783 Chinese participants aged 40-80 years who were at high risk of colorectal cancer (CRC) in the Lanxi Pre-colorectal Cancer Cohort (LP3C). Dietary information was obtained through a validated food-frequency questionnaire (FFQ), and colonoscopy screening was used to detect colorectal polyps. Dose-response associations of fruit and vegetable intake with the prevalence of polyps were calculated using multivariate-adjusted regression models, which was reported as odds ratios (ORs) with 95% confidence intervals (CIs).RESULTS:
2064 cases of colorectal polyps were ascertained in the LP3C during 2018-2019. Upon multivariable adjustments, including the diet quality, fruit consumption was inversely associated with the prevalence of polyps (P trend = 0.02). Participants in the highest tertile of fruit intake had a 25% lower risk (OR 0.75; 95% CI 0.62â0.92) compared to non-consumers, while vegetable consumption had no significant association with polyp prevalence (P trend = 0.86). In terms of colorectal histopathology and multiplicity, higher fruit intake was correlated with 24, 23, and 33% lower prevalence of small polyps (OR 0.76; 95% CI 0.62â0.94; P trend = 0.05), single polyp (OR 0.77; 95% CI 0.62â0.96; P trend = 0.04), and distal colon polyps (OR 0.67; 95% CI 0.51â0.87; P trend = 0.003), respectively.CONCLUSIONS:
Fresh fruit is suggested as a protective factor to prevent colorectal polyps in individuals at high risk of CRC, and should be underscored in dietary recommendations, particularly for high-risk populations.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Verduras
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Neoplasias Colorrectales
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Pólipos del Colon
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Dieta
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Frutas
Límite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
País como asunto:
Asia
Idioma:
En
Año:
2024
Tipo del documento:
Article