Soluble Human Lectins at the Host-Microbe Interface.
Annu Rev Biochem
; 93(1): 565-601, 2024 Aug.
Article
en En
| MEDLINE
| ID: mdl-38640018
ABSTRACT
Human lectins are integral to maintaining microbial homeostasis on the skin, in the blood, and at mucosal barriers. These proteins can recognize microbial glycans and inform the host about its microbial status. In accordance with their roles, their production can vary with tissue type. They also can have unique structural and biochemical properties, and they can influence microbial colonization at sites proximal and distal to their tissue of origin. In line with their classification as innate immune proteins, soluble lectins have long been studied in the context of acute infectious disease, but only recently have we begun to appreciate their roles in maintaining commensal microbial communities (i.e., the human microbiota). This review provides an overview of soluble lectins that operate at host-microbe interfaces, their glycan recognition properties, and their roles in physiological and pathological mechanisms.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Polisacáridos
/
Inmunidad Innata
/
Lectinas
Límite:
Animals
/
Humans
Idioma:
En
Año:
2024
Tipo del documento:
Article