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Environmental chemical-wide associations with immune biomarkers in US adults: A cross-sectional analysis.
Middleton, Lauren Y M; Nguyen, Vy K; Dou, John; Wang, Herong; Patel, Chirag J; Park, Sung Kyun; Colacino, Justin A; Bakulski, Kelly M.
  • Middleton LYM; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA; Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, USA; Medical School, University of Michigan, Ann Arbor, MI, USA.
  • Nguyen VK; Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, USA; Department of Computational Medicine and Bioinformatics, Medical School, University of Michigan, Ann Arbor, MI, USA; Department of Biomedical Informatics, Harvard Medical School, Harvard
  • Dou J; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
  • Wang H; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
  • Patel CJ; Department of Biomedical Informatics, Harvard Medical School, Harvard University, Boston, MA, USA.
  • Park SK; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA; Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
  • Colacino JA; Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, USA; Department of Nutritional Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, USA; Center for Computational Medicine and Bioinformatics, University of Michigan, Ann
  • Bakulski KM; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA. Electronic address: bakulski@umich.edu.
Environ Res ; 252(Pt 3): 118956, 2024 Jul 01.
Article en En | MEDLINE | ID: mdl-38640990
ABSTRACT
Environmental chemical exposures influence immune system functions, and humans are exposed to a wide range of chemicals, termed the chemical "exposome". A comprehensive, discovery analysis of the associations of multiple chemical families with immune biomarkers is needed. In this study, we tested the associations between environmental chemical concentrations and immune biomarkers. We analyzed the United States cross-sectional National Health and Nutrition Examination Survey (NHANES, 1999-2018). Chemical biomarker concentrations were measured in blood or urine (196 chemicals, 17 chemical families). Immune biomarkers included counts of lymphocytes, neutrophils, monocytes, basophils, eosinophils, red blood cells, white blood cells, and mean corpuscular volume. We conducted separate survey-weighted, multivariable linear regressions of each log2-transformed chemical and immune measure, adjusted for relevant covariates. We accounted for multiple comparisons using a false discovery rate (FDR). Among 45,528 adult participants, the mean age was 45.7 years, 51.4% were female, and 69.3% were Non-Hispanic White. 71 (36.2%) chemicals were associated with at least one of the eight immune biomarkers. The most chemical associations (FDR<0.05) were observed with mean corpuscular volume (36 chemicals) and red blood cell counts (35 chemicals). For example, a doubling in the concentration of cotinine was associated with 0.16 fL (95% CI 0.15, 0.17; FDR<0.001) increased mean corpuscular volume, and a doubling in the concentration of blood lead was associated with 61,736 increased red blood cells per µL (95% CI 54,335, 69,138; FDR<0.001). A wide variety of chemicals, such as metals and smoking-related compounds, were highly associated with immune system biomarkers. This environmental chemical-wide association study identified chemicals from multiple families for further toxicological, immunologic, and epidemiological investigation.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Biomarcadores / Exposición a Riesgos Ambientales Límite: Adult / Female / Humans / Male / Middle aged País como asunto: America do norte Idioma: En Año: 2024 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Biomarcadores / Exposición a Riesgos Ambientales Límite: Adult / Female / Humans / Male / Middle aged País como asunto: America do norte Idioma: En Año: 2024 Tipo del documento: Article