Risk and predictors of penile cancer in US Veterans with HIV.
AIDS
; 38(9): 1395-1401, 2024 07 15.
Article
en En
| MEDLINE
| ID: mdl-38652491
ABSTRACT
OBJECTIVES:
People with HIV (PWH) may have an increased burden of penile cancer. We aimed to evaluate the risk of penile cancer in PWH compared with that of the general population.DESIGN:
We conducted a nationwide retrospective matched cohort study of penile cancer incidence among veterans with HIV (VWH) compared with veterans without HIV.METHODS:
We compared penile cancer incidence rates in 44â173 VWH to those of veterans without HIV ( N â=â159â443; 4ââ1 matched in age). We used Cox regression models to estimate hazard ratios and 95% confidence intervals (CIs) for associations with HIV infection and for penile cancer risk factors.RESULTS:
HIV positivity was associated with an increased risk of penile cancer, with adjusted hazard ratios of 2.63 (95% CI 1.64-4.23) when adjusting for age, race/ethnicity, baseline BMI, smoking and alcohol use, economic means test, and history of condyloma. The risk increased to hazard ratioâ=â4.25 (95% CI 2.75-6.57) when adjusting for all factors except history of condyloma. Risk factors for penile cancer in VWH included lower nadir CD4 + count, less than 50% of follow-up time with undetectable HIV viral load, and history of condyloma.CONCLUSION:
VWH - particularly those with low CD4 + counts, detectable HIV viral loads, or history of condyloma - are at increased risk of penile cancer, suggesting the penile cancer prevention activities are needed in this population.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias del Pene
/
Veteranos
/
Infecciones por VIH
Límite:
Adult
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Aged
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Humans
/
Male
/
Middle aged
País como asunto:
America do norte
Idioma:
En
Año:
2024
Tipo del documento:
Article