A dietary commensal microbe enhances antitumor immunity by activating tumor macrophages to sequester iron.
Nat Immunol
; 25(5): 790-801, 2024 May.
Article
en En
| MEDLINE
| ID: mdl-38664585
ABSTRACT
Innate immune cells generate a multifaceted antitumor immune response, including the conservation of essential nutrients such as iron. These cells can be modulated by commensal bacteria; however, identifying and understanding how this occurs is a challenge. Here we show that the food commensal Lactiplantibacillus plantarum IMB19 augments antitumor immunity in syngeneic and xenograft mouse tumor models. Its capsular heteropolysaccharide is the major effector molecule, functioning as a ligand for TLR2. In a two-pronged manner, it skews tumor-associated macrophages to a classically active phenotype, leading to generation of a sustained CD8+ T cell response, and triggers macrophage 'nutritional immunity' to deploy the high-affinity iron transporter lipocalin-2 for capturing and sequestering iron in the tumor microenvironment. This process induces a cycle of tumor cell death, epitope expansion and subsequent tumor clearance. Together these data indicate that food commensals might be identified and developed into 'oncobiotics' for a multi-layered approach to cancer therapy.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Microambiente Tumoral
/
Hierro
Límite:
Animals
/
Female
/
Humans
Idioma:
En
Año:
2024
Tipo del documento:
Article