Kinetics of Hepatitis E Virus Infections in Asymptomatic Persons.
Emerg Infect Dis
; 30(5): 934-940, 2024 May.
Article
en En
| MEDLINE
| ID: mdl-38666600
ABSTRACT
To determine the kinetics of hepatitis E virus (HEV) in asymptomatic persons and to evaluate viral load doubling time and half-life, we retrospectively tested samples retained from 32 HEV RNA-positive asymptomatic blood donors in Germany. Close-meshed monitoring of viral load and seroconversion in intervals of ≈4 days provided more information about the kinetics of asymptomatic HEV infections. We determined that a typical median infection began with PCR-detectable viremia at 36 days and a maximum viral load of 2.0 × 104 IU/mL. Viremia doubled in 2.4 days and had a half-life of 1.6 days. HEV IgM started to rise on about day 33 and peaked on day 36; IgG started to rise on about day 32 and peaked on day 53. Although HEV IgG titers remained stable, IgM titers became undetectable in 40% of donors. Knowledge of the dynamics of HEV viremia is useful for assessing the risk for transfusion-transmitted hepatitis E.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Viremia
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Donantes de Sangre
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ARN Viral
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Virus de la Hepatitis E
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Hepatitis E
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Carga Viral
Límite:
Adult
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Female
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Humans
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Male
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Middle aged
País como asunto:
Europa
Idioma:
En
Año:
2024
Tipo del documento:
Article