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Inside the Host: Understanding the Evolutionary Trajectories of Intracellular Parasitism.
Bartosová-Sojková, Pavla; Butenko, Anzhelika; Richtová, Jitka; Fiala, Ivan; Oborník, Miroslav; Lukes, Julius.
  • Bartosová-Sojková P; 1Institute of Parasitology, Biology Centre, Czech Academy of Sciences, Ceské Budejovice, Czech Republic; email: bartosova@paru.cas.cz, jula@paru.cas.cz, obornik@paru.cas.cz.
  • Butenko A; 1Institute of Parasitology, Biology Centre, Czech Academy of Sciences, Ceské Budejovice, Czech Republic; email: bartosova@paru.cas.cz, jula@paru.cas.cz, obornik@paru.cas.cz.
  • Richtová J; 2Faculty of Science, University of South Bohemia in Ceské Budejovice, Ceské Budejovice, Czech Republic.
  • Fiala I; 3Life Science Research Centre, Faculty of Science, University of Ostrava, Ostrava, Czech Republic.
  • Oborník M; 1Institute of Parasitology, Biology Centre, Czech Academy of Sciences, Ceské Budejovice, Czech Republic; email: bartosova@paru.cas.cz, jula@paru.cas.cz, obornik@paru.cas.cz.
  • Lukes J; 1Institute of Parasitology, Biology Centre, Czech Academy of Sciences, Ceské Budejovice, Czech Republic; email: bartosova@paru.cas.cz, jula@paru.cas.cz, obornik@paru.cas.cz.
Annu Rev Microbiol ; 2024 Apr 29.
Article en En | MEDLINE | ID: mdl-38684082
ABSTRACT
This review explores the origins of intracellular parasitism, an intriguing facet of symbiosis, where one organism harms its host, potentially becoming deadly. We focus on three distantly related groups of single-celled eukaryotes, namely Kinetoplastea, Holomycota, and Apicomplexa, which contain multiple species-rich lineages of intracellular parasites. Using comparative analysis of morphological, physiological, and molecular features of kinetoplastids, microsporidians, and sporozoans, as well as their closest free-living relatives, we reveal the evolutionary trajectories and adaptations that enabled the transition to intracellular parasitism. Intracellular parasites have evolved various efficient mechanisms for host acquisition and exploitation, allowing them to thrive in a variety of hosts. Each group has developed unique features related to the parasitic lifestyle, involving dedicated protein families associated with host cell invasion, survival, and exit. Indeed, parallel evolution has led to distinct lineages of intracellular parasites employing diverse traits and approaches to achieve similar outcomes.

Texto completo: 1 Banco de datos: MEDLINE Idioma: En Año: 2024 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Idioma: En Año: 2024 Tipo del documento: Article