When prion disease Isn't suspected: prion disease as the cause of terminal decline in chronic mixed dementia.
Neurocase
; 29(3): 92-97, 2023 06.
Article
en En
| MEDLINE
| ID: mdl-38687122
ABSTRACT
Alzheimer's Disease (AD) is the most common cause of dementia, although multiple pathologies are found in nearly half of the cases with clinically diagnosed AD. Prion diseases, such as Creutzfeldt-Jakob disease (CJD), are rare causes of dementia and typically manifest as a rapidly progressive dementia, where symptom onset to dementia most often occurs over the course of months. In this brief report, we describe a patient's typically progressive dementia with a precipitous decline at the end of their life who, on neuropathological evaluation, was found to have multiple neurodegenerative proteinopathies as well as spongiform encephalopathy due to CJD. This case of unsuspected CJD highlights a rare, but epidemiologically important, cause of sudden decline in well-established neurodegenerative dementias.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Síndrome de Creutzfeldt-Jakob
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Demencia
Límite:
Aged
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Female
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Humans
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Male
Idioma:
En
Año:
2023
Tipo del documento:
Article