The Effect of Propofol on the Hippocampus in Chronic Cerebral Hypoxia in a Rat Model Through Klotho Regulation.
In Vivo
; 38(3): 1162-1169, 2024.
Article
en En
| MEDLINE
| ID: mdl-38688607
ABSTRACT
BACKGROUND/AIM:
Chronic cerebral hypoxia often leads to brain damage and inflammation. Propofol is suggested to have neuroprotective effects under anaesthesia. MATERIALS ANDMETHODS:
This study used rat models with carotid artery coarctation or closure. Four groups of rats were compared a control group, a propofol-treated group, a group with bilateral common carotid artery blockage (BCAO), and a BCAO group treated with propofol post-surgery.RESULTS:
The Morris water maze test indicated cognitive impairment in BCAO rats, which also showed hippocampal structure changes, oxidative stress markers alteration, and reduced Klotho expression. Propofol treatment post-BCAO surgery improved these outcomes, suggesting its potential in mitigating chronic cerebral hypoxia effects.CONCLUSION:
Propofol may increase klotho levels and reduce apoptosis and inflammation linked to oxidative stress in cognitively impaired mice.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Propofol
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Hipoxia Encefálica
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Estrés Oxidativo
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Modelos Animales de Enfermedad
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Proteínas Klotho
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Glucuronidasa
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Hipocampo
Límite:
Animals
Idioma:
En
Año:
2024
Tipo del documento:
Article