Two remarkable serine/leucine polymorphisms in Helicobacter pylori: functional importance for serine protease HtrA and adhesin BabA.
Cell Commun Signal
; 22(1): 250, 2024 May 02.
Article
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| MEDLINE
| ID: mdl-38698410
ABSTRACT
Single nucleotide polymorphisms (SNPs) account for significant genomic variability in microbes, including the highly diverse gastric pathogen Helicobacter pylori. However, data on the effects of specific SNPs in pathogen-host interactions are scarce. Recent functional studies unravelled how a serine/leucine polymorphism in serine protease HtrA affects the formation of proteolytically active trimers and modulates cleavage of host cell-to-cell junction proteins during infection. A similar serine/leucine mutation in the carbohydrate binding domain of the adhesin BabA controls binding of ABO blood group antigens, enabling binding of either only the short Lewis b/H antigens of blood group O or also the larger antigens of blood groups A and B. Here we summarize the functional importance of these two remarkable bacterial SNPs and their effect on the outcome of pathogen-host interactions.
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Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Serina
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Helicobacter pylori
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Adhesinas Bacterianas
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Leucina
Límite:
Animals
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Humans
Idioma:
En
Año:
2024
Tipo del documento:
Article