Polymorphic transposable elements provide new insights on high-altitude adaptation in the Tibetan Plateau.
Genomics
; 116(3): 110854, 2024 05.
Article
en En
| MEDLINE
| ID: mdl-38701989
ABSTRACT
Several studies demonstrated that populations living in the Tibetan plateau are genetically and physiologically adapted to high-altitude conditions, showing genomic signatures ascribable to the action of natural selection. However, so far most of them relied solely on inferences drawn from the analysis of coding variants and point mutations. To fill this gap, we focused on the possible role of polymorphic transposable elements in influencing the adaptation of Tibetan and Sherpa highlanders. To do so, we compared high-altitude and middle/low-lander individuals of East Asian ancestry by performing in silico analyses and differentiation tests on 118 modern and ancient samples. We detected several transposable elements associated with high altitude, which map genes involved in cardiovascular, hematological, chem-dependent and respiratory conditions, suggesting that metabolic and signaling pathways taking part in these functions are disproportionately impacted by the effect of environmental stressors in high-altitude individuals. To our knowledge, our study is the first hinting to a possible role of transposable elements in the adaptation of Tibetan and Sherpa highlanders.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Elementos Transponibles de ADN
/
Altitud
Límite:
Humans
País como asunto:
Asia
Idioma:
En
Año:
2024
Tipo del documento:
Article