Fine particulate matter (PM2.5) promotes chemoresistance and aggressive phenotype of A549 lung cancer cells.
Toxicol Appl Pharmacol
; 487: 116955, 2024 Jun.
Article
en En
| MEDLINE
| ID: mdl-38710373
ABSTRACT
Lung cancer is one of the most aggressive malignancies with a high mortality rate. In large cities, particulate matter (PM) is a common air pollutant. High PM levels with aerodynamic size ≤2.5 µm (PM2.5) associates with lung cancer incidence and mortality. In this work, we explored PM2.5 effects on the behavior of lung cancer cells. To this, we chronically exposed A549 cells to increasing PM2.5 concentrations collected in México City, then evaluating cell proliferation, chemoresponse, migration, invasion, spheroid formation, and P-glycoprotein and N-cadherin expression. Chronic PM2.5 exposure from 1 µg/cm2 stimulated A549 cell proliferation, migration, and chemoresistance and upregulated P-glycoprotein and N-cadherin expression. PM2.5 also induced larger multicellular tumor spheroids (MCTS) and less disintegration compared with control cells. Therefore, these results indicate lung cancer patients exposed to airborne PM2.5 as urban pollutant could develop more aggressive tumor phenotypes, with increased cell proliferation, migration, and chemoresistance.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Movimiento Celular
/
Resistencia a Antineoplásicos
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Proliferación Celular
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Contaminantes Atmosféricos
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Material Particulado
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Neoplasias Pulmonares
Límite:
Humans
País como asunto:
Mexico
Idioma:
En
Año:
2024
Tipo del documento:
Article